THE HIGH AFFINITY PERIPHERAL BENZODIAZEPINE RECEPTOR LIGAND DAA1106 BINDS TO ACTIVATED AND INFECTED BRAIN MACROPHAGES IN AREAS OF SYNAPTIC DEGENERATION: IMPLICATIONS FOR PET IMAGING OF NEUROINFLAMMATION IN LENTIVIRAL ENCEPHALITIS

HIV encephalitis (HIVE) is characterized by neurodegeneration mediated by toxins derived from infected and activated brain macrophages.Since the peripheral benzodiazepine receptor (PBR) is abundant on brain macrophages, we hypothesized that [3H]DAA1106, a new PBR ligand, can label infected and activated brain macrophages in HIVE.Using cell culture

BACKGROUND AND METHODS: To guide achievement of the Millennium Development Goals, we used the Lives Saved Tool to provide a novel simulation of potential maternal, fetal, and newborn lives and costs saved by scaling up midwifery and obstetrics services, including family planning, in 58 low- and middle-income countries.Typical midwifery and obstetri

The application of functional imaging to study painful sensations has generated considerable interest regarding insight into brain dysfunction that may be responsible for functional pain such as that suffered in patients with irritable bowel syndrome (IBS).This review provides a brief introduction to Arnica the development of brain science as it re

Siba Prosad Paul,1 Rachel Pouf Wilkinson,2 Christine Routley3 1Southmead Hospital, Bristol, 2St Richard's Hospital, Chichester, 3Paediatric Services, Yeovil District Hospital, Yeovil, UK Abstract: Respiratory tract infections (RTIs) in children are one of the most common reasons for parents consulting health professionals.Most RTIs are self-lim